About the ISPCTN

About the ECHO ISPCTN

The Institutional Development Award (IDeA) program builds research capacities in states that historically have had low levels of NIH funding by supporting basic, clinical, and translational research; faculty development; and infrastructure improvements. The program also enhances the ability of investigators to compete successfully for additional research funding and serves the research needs of medically underserved communities.

ECHO leverages NIH-funded institutions that are part of the IDeA Program to build an ECHO IDeA States Pediatric Clinical Trials Network (ISPCTN). The goal of the ECHO ISPCTN is to provide medically underserved and rural populations with access to state-of-the-art clinical trials, apply findings from relevant pediatric cohort studies to children in IDeA state locations, and build pediatric research capacity at a national level. Funding also supports professional development of faculty-level pediatricians and their support teams in the conduct of clinical trials research.

Portrait Of Girl With Friends Eating Healthy Picnic At Outdoor Table In Countryside

ECHO ISPCTN Manuscripts

  1. The institutional development award IDeA States Pediatric Clinical Trials Network: building research capacity among the rural and medically underserved. Current Opinion Pediatric. 2018 Apr;30(2):297-302. PMID: 29517535; PMCID: PMC5927618.
  2. IDeA States Pediatric Clinical Trials Network for underserved and rural communities. Pediatrics. 2020 Oct;146(4):e20200290. PMID: 32943534; PMCID: PMC7786822.
  3. Team science process builds research coordinators’ voices in a national pediatric clinical trials network. SOCRA Source. 2020;105:68-73.
  4. Capacity building for a new multicenter network within the ECHO IDeA States Pediatric Clinical Trials Network. Frontiers in Pediatrics. 2021;July 14(9):679516. PMID: 34336738; PMCID: PMC8316720.
  5. Best practices for conducting clinical trials with Indigenous children in the U.S. American Journal of Public Health. 2021;Sep 111(9):1645-1653. PMID: 34436921; PMCID: PMC8494399.
  6. Environmental influences on Child Health Outcomes (ECHO) Institutional Development Award (IDeA) States Pediatric Clinical Trials Network. Capacity building in a new clinical trials network through inter-network collaboration. Journal of Pediatrics. 2022;Jan 1;240:5-8. PMID: 33940019; PMCID: PMC9047255. DOI: 10.1016/j.jpeds.2021.04.062.
  7. Facilitators and Barriers to Pediatric Clinical Trial Recruitment and Retention in Rural and Community Settings: A Scoping Review of the Literature. Clin Transl Sci. 2022 Jan 17. DOI: 10.1111/cts.13220. Epub ahead of print. PMID: 35037409; PMCID: PMC9010274.
  8. Pharmacokinetics of oral vitamin D in children with obesity and asthma. Clin Pharmacokinetics. 2023;Aug 30:online; PMID: 37646988; PMCID: 10598621.
  9. COVID-19 Vaccine Hesitancy Among Parents: A Qualitative Study. Pediatrics. 2023; Oct 23;152(5):e2023062466. doi: 10.1542/peds.2023-062466. PMID: 37867449; PMCID: 10598621.

ECHO ISPCTN Research Summaries

Influence of Eat, Sleep, and Console on Infants Pharmacologically Treated for Opioid Withdrawal: A Post Hoc Subgroup Analysis of the ESC-NOW Randomized Clinical Trial
Author(s): Lori A. Devlin, Zhuopei Hu, Stephanie L. Merhar, et al.

Can People Living in Rural Areas Accurately Measure Their Height and Weight at Home?
Author(s): E (Alice) Zhang, Ann M. Davis, Elizabeth Yakes Jimenez, et al.

A Qualitative Exploration of COVID-19 Vaccine Hesitancy Among Parents
Authors: Aubree Honcoop, James R Roberts, Boyd Davis, et al.

How Much Vitamin D do Children with Asthma and Increased Body Weight Need to Correct Low Vitamin D Levels?
Authors: Jason E. Lang, Rodrigo Gonzalez Ramirez, Stephen Balevic, et al.

Rural Family Satisfaction with Telehealth Delivery of an Intervention for Pediatric Obesity and Associated Family Characteristics
En Español
Author(s): Nguyen L, Phan TL, Falini L, et al.

“Eat, Sleep, Console” approach shown to be more effective in caring for newborns with neonatal opioid withdrawal syndrome
En Español
Author(s): Leslie Young, Lori Devlin, Stephanie Merhar, et al.

The ACT NOW Clinical Practice Survey: Gaps in the Care of Infants With Neonatal Opioid Withdrawal Syndrome
En Español
Author(s): Jessica Snowden, Akshatha, Robert Annett, et al.

Site-Level Variation in the Characteristics and Care of Infants with Neonatal Opioid Withdrawal
En Español
Author(s): Leslie Young, Zhuopei Hu, Robert Annett, et al.

The Influence of Mediators on the Relationship Between Antenatal Opioid Agonist Exposure and the Severity of Neonatal Opioid Withdrawal Syndrome
En Español
Author(s): Lori A. Devlin, Zhuopei Hu, Songthip Ounpraseuth, et al.

Conducting a Pediatric Randomized Clinical Trial During a Pandemic: A Shift to Virtual Procedures
En Español
Author(s): James Roberts, Sheva Chervinskiy, Russell McCulloh, et al.

Facilitators and Barriers to Pediatric Clinical Trial Recruitment and Retention in Rural and Community Settings: A Scoping Review of the Literature
En Español
Author(s): Sara E. Watson, Paul Smith, Jessica Snowden, et al.

Best Practices for Conducting Clinical Trials with Indigenous Children in the United States
En Español
Author(s): Jennifer Shaw, Erin Semmens, May Okihiro, et al.

Phenobarbital and Clonidine as Secondary Medications for Neonatal Opioid Withdrawal Syndrome
En Español
Author(s): Stephanie Merhar, Songthip Ounpraseuth, Lori Devlin, et al.

Training as an Intervention to Decrease Medical Record Abstraction Errors Multicenter Studies
En Español
Author(s): Meredith Zozus, Leslie Young, Alan Simon, et al.