Exposure to Air Pollution During Pregnancy Associated with Higher Risk for Autism-related Outcomes

Posted on by Jodi Snare

Exposure to certain air pollutants during pregnancy was associated with autism-related traits and increased odds of autism spectrum disorder (ASD) diagnosis in children, according to a recent ECHO Cohort study led by Akhgar Ghassabian, MD, PhD of NYU Grossman School of Medicine and Heather Volk, PhD of Johns Hopkins Bloomberg School of Public Health.

Air pollution is a significant environmental health concern and contributes to many illnesses and early deaths worldwide. Ambient air pollution can have detectable effects on the brain. Recent studies show that being exposed to air pollution during pregnancy and early life can affect how a child’s brain develops. This can happen through several pathways, such as causing inflammation in the brain, disrupting hormones, or changing how genes work. Previous research has suggested potential links between air pollution and neurodevelopmental disorders, but the relationship between exposure to air pollution, even at low levels, during pregnancy and ASD has been unclear.

This study included 8,035 mother-child pairs from 44 ECHO Cohort study sites, including over 1,000 children who were potentially at higher risk for ASD based on being born preterm or having siblings with autism.

Key takeaways include:

  • Prenatal exposure to ozone was associated with autism-related traits and increased risk of ASD diagnosis.
  • Exposure to fine particulate matter (PM5) and nitrogen dioxide was also associated with a higher risk of autism, but associations varied by geographical regions.
  • There was little evidence for differences between boys and girls in the association between prenatal air pollution exposure and autism outcomes.

These findings suggest that even low levels of air pollution exposure during pregnancy can be associated with autism-related outcomes. This highlights the importance of understanding the risks associated with air pollution exposure during pregnancy and its effects on neurodevelopment.

This collaborative research, titled “Prenatal Air Pollution Exposure and Autism Spectrum Disorder in the ECHO Consortium,” is published in Environmental Health Perspectives.