pregnancy

NIH Study Explores Pollution Exposure and Birth Outcomes in Pregnant Women Living in Historically Redlined Neighborhoods

Posted on by Jodi Snare

Residence in redlined census tracts during pregnancy was associated with higher exposure to PM2.5 and lower birth weight in a recent study funded by the Environmental influences on Child Health Outcomes (ECHO) Program. Redlining is the historical practice of designating certain neighborhoods, often where minority groups lived, as risky investments for lenders. Additionally, living in ungraded census tracts was linked to elevated PM2.5 exposure, lower birth weight, and increased odds of low birth weight. These findings underscore the complex nature of structural racism, suggesting that factors beyond redlining may contribute to ongoing inequalities in health outcomes. Further research is needed to explore these dynamics and their implications for maternal and infant health. Read the research summary here.

ECHO Study Investigates Exposure to Flame-Retardants During Pregnancy and Childhood Obesity Risk

ECHO Study Investigates Exposure to Flame-Retardants During Pregnancy and Childhood Obesity Risk

Authors: Alicia K. Peterson, Assiamira Ferrara, et al.

 

Who sponsored this study?

The Environmental influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health supported this research.

 

Why was this study needed?

Organophosphate esters (OPE) replaced polybrominated diphenyl ethers (PBDEs) as flame retardants and plastic softeners in the mid-2000s. They are now present in various household and industrial products, including polyurethane foam, furniture, electronics, construction materials, infant products, textiles, and fabrics. Health officials have raised concerns about their impact on hormone systems and potential links to obesity. This study looked at whether the levels of OPEs found in a mother's urine during pregnancy were associated with a higher risk of obesity in her child.

 

What were the study results?

The study found varying associations between gestational OPE exposure and childhood obesity.  The study found that children aged 5 to 10 years who were exposed to higher levels of dibutyl phosphate and di-isobutyl phosphate (DBUP/DIBP) during their mother’s pregnancy had a 14% greater risk of developing obesity compared to those with the lowest exposure levels. In contrast, children whose mothers had higher exposure levels of bis (1,3-dichloro-2-propyl) phosphate (BDCPP) during their mother’s pregnancy had a 15% lower risk of developing obesity than those with the lowest levels of exposure. Researchers measured for evidence of nine different OPEs in pregnant participants’ urine. Evidence of exposure to DBUP/DIBP and BDCPP was present in more than 80% of the samples. No association with obesity risk was observed for the rest of the OPEs measured.

 

What was this study's impact?

The study highlights the potential public health issue of gestational OPE exposure and its association with childhood obesity. It suggests the need for further investigation across a broad range of OPE exposures and could inform potential regulations on the manufacture and use of OPEs.

 

Who was involved?

The study involved 5,087 individuals from 14 ECHO Cohort Study Sites. The study population was geographically, racially, and ethnically diverse.

 

What happened during the study?

Researchers measured OPE exposure in the urine samples of pregnant participants between 2006 and 2020 and collected BMI measurements for the children from infancy to age 10 years.

Note: Results reported here are for a single study. Other or future studies may provide new information or different results. You should not make changes to your health without first consulting your healthcare professional.

 

What happens next?

Further studies could help researchers better understand the associations between gestational exposure across a broad range of OPE exposures and childhood obesity.

 

Where can I learn more?

Access the full journal article, “Gestational Exposure to Organophosphate Ester Flame Retardants and Risk of Childhood Obesity in the Environmental influences on Child Health Outcomes Consortium,” in Environment International.

 

The content is the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 

Published October 17, 2024

 

Read the associated press release.

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ECHO Study Investigates Exposure to Flame-Retardants During Pregnancy and Childhood Obesity Risk

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ECHO Study Evaluates Influence of Neighborhood-Level Poverty and Food Insecurity During Pregnancy on Birthweight

Authors: Izzuddin Aris, Emily Oken, et al.

Weight Gain During Infancy in Children Born Preterm Associated with Higher Risk of Obesity, According to New ECHO Research

Authors: Michael O’Shea, et al.

ECHO Study Suggests No Association Between Maternal Stress in the First Year After Birth and Childhood BMI

Authors: Callie Brown, Charles Wood, et al.

ECHO Study Finds Maternal Stress During and After Pregnancy May Be Linked to Child Sleep Problems

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ECHO Study Finds Maternal Stress During and After Pregnancy May Be Linked to Child Sleep Problems

Authors: Sarah Dee Geiger, Aruna Chandran, Marie L. Churchill, Susan Schantz et al.

 

Who sponsored this study?

The Environmental influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health supported this research.

 

Why was this study needed?

This study aimed to explore the associations between perceived maternal stress during and after pregnancy and child sleep problems and disturbances. Previous research has suggested prenatal stress could be associated with negative child sleep outcomes, but less is known about how postnatal stress may contribute to this association. This study aimed to address these gaps and provide insights into the potential public health implications of stress during and after pregnancy.

 

What were the study results?

The study found that maternal stress during pregnancy showed a small but significant association with child sleep problems and sleep disturbance. This effect was seen even when the researchers accounted for the influence of maternal stress after pregnancy.

 

What was the study's impact?

Maternal stress during and after pregnancy and child sleep problems are both very common, so even small effects may have important public health implications. Interventions that can help mothers manage stress during and after pregnancy could have positive effects on their children’s sleep quality, setting them up for a healthier childhood and adulthood.

 

Who was involved?

This study used data from a diverse group of 1,965 mother-child pairs enrolled in ECHO Study Sites in 7 U.S. states and Puerto Rico. The study included mothers who reported their stress during and after pregnancy and their child’s sleep at least once between the ages of 4 and 8, resulting in a racially and ethnically diverse sample, with up to 50% of these children being reported as Hispanic by their parents.

 

What happened during the study?

During the study, researchers measured maternal perceived stress using the Perceived Stress Scale (PSS) and used statistical analysis to investigate the relationship between maternal stress during pregnancy and child sleep quality, adjusting for various factors such as the mother’s age at delivery and level of education and the child’s sex, gestational age at birth, and age when sleep was evaluated. The researchers also conducted an analysis to assess the degree to which stress after pregnancy affected the relationship between prenatal stress and child sleep quality.

Footnote: Results reported here are for a single study. Other or future studies may provide new information or different results. You should not make changes to your health without first consulting your healthcare professional.

What happens next?

Additional studies can help researchers understand the relationship between prenatal stress and child sleep outcomes. Future studies could also investigate the biological mechanisms and social factors underlying the association between prenatal stress and sleep outcomes in childhood.

 

Where can I learn more?

Access the full journal article, titled “Association Between Maternal Stress and Child Sleep Quality: A Nationwide Environmental Influences on Child Health Outcomes Program Prospective Cohort Study,” in Pediatric Research.

 

The content is the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Published October 11, 2024

 

Access the associated article.

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ECHO Study Finds Maternal Stress During and After Pregnancy May Be Linked to Child Sleep Problems

Vulnerable Populations More Likely to be Impacted by Small Environmental Effects, ECHO Study Finds

Vulnerable Populations More Likely to be Impacted by Small Environmental Effects, ECHO Study Finds

Authors: Janet L. Peacock, et al.

 

Who sponsored this study?

The Environmental influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health supported this research.

 

Why was this study needed?

A challenge in public health is determining when the effect of an environmental exposure is large enough to be clinically important. Vulnerable populations—defined by sociodemographic factors such as race, ethnicity, and maternal education—tend to have a higher risk of poor health outcomes than the general population when exposed to the same environmental exposures. This study aimed to interpret the differences in outcomes between different population types, particularly focusing on vulnerable sub-populations, by analyzing differences arising from hypothetical small effects on these groups.

 

What were the study results?

The researchers used statistical models to examine how different levels of exposures would affect different sub-populations within the nationwide ECHO Cohort. Specifically, the study team considered a hypothetical environmental exposure that could affect a child’s birthweight. They considered four scenarios in which the hypothetical exposure could affect average birthweights in a population: a very small effect reducing average birthweight by 50g, a small effect reducing it by 125g, a medium effect reducing it by 167g, and a large effect reducing it by 250g.

The study found that the percentage of children with low birthweight (LBW) (birthweight<2500g) varied by socioeconomic categories with the greatest percentage LBW seen in the most vulnerable socioeconomic groups. After analyzing the four scenarios, a clear trend was seen such that the greatest impact of an exposure was seen in the most vulnerable sub-populations. This trend was observed for all scenarios including the impact of a small environmental exposure.

 

What was this study's impact?

This study showed how vulnerable groups, who already face higher risks of poor health, may be more affected by small environmental exposures than the general population. This demonstrates why small effects, which may be overlooked, are actually important when considering vulnerable populations. These results can be used in planning future studies and for designing preventive programs. The findings also help explain how exposures impact vulnerable groups and highlight the need to stratify by socioeconomic variables when assessing health outcomes.

 

Who was involved?

This simulation study modeled data from more than 28,000 mother-child pairs from the ECHO Cohort.

 

What happened during the study?

The research team conducted a simulation using data from ECHO Cohort participants to explore how hypothetical exposures could affect babies’ average birthweight and LBW in vulnerable subgroups. The study calculated average birthweight in groups by sociodemographic categories, and then compared the differences in average birthweight and the percentage of LBW.

Footnote: Results reported here are for a single study. Other or future studies may provide new information or different results. You should not make changes to your health without first consulting your healthcare professional.

 

What happens next?

These findings are relevant for studies where researchers aim to identify the adverse effects of environmental exposures. Future research that uses more social factors and/or outcomes is needed to understand the impact of small environmental exposures on the general population and vulnerable sub-populations, and how these effects contribute to health disparities.

 

Where can I learn more?

Access the full journal article, titled “Do Small Effects Matter More in Vulnerable Populations? An Investigation Using Environmental influences on Child Health Outcomes (ECHO) Cohorts,” in BMC Public Health.

 

The content is the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 

Published September 28, 2024

 

Read the associated research alert.

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Vulnerable Populations More Likely to be Impacted by Small Environmental Effects, ECHO Study Finds

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ECHO Study Evaluates Influence of Neighborhood-Level Poverty and Food Insecurity During Pregnancy on Birthweight

Authors: Izzuddin Aris, Emily Oken, et al.

Weight Gain During Infancy in Children Born Preterm Associated with Higher Risk of Obesity, According to New ECHO Research

Authors: Michael O’Shea, et al.

ECHO Study Suggests No Association Between Maternal Stress in the First Year After Birth and Childhood BMI

Authors: Callie Brown, Charles Wood, et al.

Food Insecurity in Pregnancy & Early Life May Be Linked to Higher Chance of Obesity in Children & Adolescents

Food Insecurity in Pregnancy & Early Life May Be Linked to Higher Chance of Obesity in Children & Adolescents

Authors: Izzuddin M. Aris, et al

 

Who sponsored this study?

The Environmental influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health supported this research.

 

Why was this study needed?

Previous studies have linked food insecurity with obesity in adults, but evidence around the impact in children isn’t as clear. Many of these studies have looked at food insecurity and obesity at a single point in time rather than following the children over time. Because of this, it’s difficult to understand whether childhood obesity is directly influenced by food insecurity. Additionally, the few long-term studies that have addressed food insecurity and childhood obesity have primarily focused on late childhood or adolescence. ECHO Cohort researchers aimed to explore how food insecurity during pregnancy and early life—stages that may be particularly important to influencing long-term health outcomes—could be related to obesity in childhood and adolescence.

 

What were the study results?

Children who lived in low-income, low-food-access (LILA) neighborhoods during early childhood or whose mothers lived there during pregnancy were found to have higher body mass index (BMI) at ages 5 and 15. Living in those conditions was also associated with a 50% greater chance of developing obesity or severe obesity at ages 5, 10, and 15 years—regardless of individual sociodemographic factors. The association was strongest for those living in LILA neighborhoods during early childhood and their mother’s pregnancy. A LILA neighborhood is defined as a low-income neighborhood where a third or more residents live more than one half mile from a grocery store in urban areas or more than 10 miles in rural areas.

 

What was this study's impact?

These findings suggest that pregnancy and early childhood may be life stages when neighborhood food access can play the biggest role in long-term health outcomes. Living in neighborhoods with access to healthy foods during these stages may be important in preventing the development of obesity later in childhood and adolescence.

 

Who was involved?

The study included 28,359 participants from 55 ECHO Cohort Study Sites, including racially, ethnically, and geographically diverse mother-child pairs. Approximately 23% of the participants lived in a LILA neighborhood during pregnancy, and around 24% lived in these areas during early childhood.

 

What happened during the study?

Researchers mapped out where participants lived during pregnancy (from 1994 to 2023) or early childhood (from 1999 to 2023), matching each address to a specific neighborhood based on census data. They then linked these neighborhoods to food access data from the USDA Food Access Research Atlas for the years closest to when the participants lived there. The database offers information on household income, vehicle availability, and food access in neighborhoods.

Child weight and height data were collected from birth to adolescence through in-person research visits, medical records, and parent or caregiver reports. Researchers compared this data with information on where the children lived to determine if there was a link between neighborhood food access and child BMI or obesity.

Note: Results reported here are for a single study. Other or future studies may provide new information or different results. You should not make changes to your health without first consulting your healthcare professional.

 

What happens next?

Future studies are needed to learn whether improving access to healthy food early in life helps prevent childhood obesity. Improvements could include encouraging new supermarkets in existing food deserts, offering healthy food options at food pantries, or making healthier choices available in small retail and convenience stores.

 

Where can I learn more?

Access the full journal article, titled “Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity,” in JAMA Pediatrics.

 

The content is the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 

Published September 16, 2024

 

Read the associated article.

Download this summary

Food Insecurity in Pregnancy & Early Life May Be Linked to Higher Chance of Obesity in Children & Adolescents

Read More Research Summaries

ECHO Study Evaluates Influence of Neighborhood-Level Poverty and Food Insecurity During Pregnancy on Birthweight

Authors: Izzuddin Aris, Emily Oken, et al.

Weight Gain During Infancy in Children Born Preterm Associated with Higher Risk of Obesity, According to New ECHO Research

Authors: Michael O’Shea, et al.

ECHO Study Suggests No Association Between Maternal Stress in the First Year After Birth and Childhood BMI

Authors: Callie Brown, Charles Wood, et al.

Food Insecurity in Early Life, Pregnancy May Be Linked to Higher Chance of Obesity in Children, NIH-Funded Study Finds

Posted on by Jodi Snare

FOR IMMEDIATE RELEASE

 

Family in grocery store

The study explores the effects of low-income, low-food-access neighborhoods on children’s obesity over time.

Children who faced food insecurity during early childhood—or whose mothers experienced it during pregnancy—had a higher body mass index (BMI) and more than 50% increased chance of developing obesity or severe obesity in childhood and adolescence, according to a new study funded by the NIH Environmental influences on Child Health Outcomes (ECHO) Program.

While previous research has linked food insecurity to obesity in adults, its impact on children is less clear. ECHO Cohort researchers explored how food insecurity during early life and pregnancy may affect the incidence of obesity in childhood and adolescence.

“Living in neighborhoods with access to healthy foods during these stages may be an important factor in preventing the development of obesity later in childhood and adolescence,” said Izzuddin M. Aris, PhD of the Harvard Pilgrim Health Care Institute. “Our findings support the need for further research on strategies to improve access to healthy food in early life.”

The study looked at data from nearly 30,000 mother-child pairs from 55 ECHO Cohort research sites nationwide. About 23% had mothers who lived in an area with limited access to grocery stores during pregnancy, and around 24% of the children lived in these areas during early childhood. Low-income-low-food-access (LILA) refers to a neighborhood with a third or more residents living more than one-half mile from a grocery store in urban areas or more than 10 miles in rural areas.

Key findings include:

  • Living in LILA neighborhoods during pregnancy or early childhood was associated with a higher BMI in the child at ages 5 and 15 and a more than 50% higher chance of developing obesity or severe obesity at ages 5, 10, and 15.
  • The associations became stronger as the children aged and were strongest among those who lived in LILA neighborhoods during early childhood and their mother’s pregnancy.

Researchers used participants' residential addresses from either pregnancy (1994 to 2023) or early childhood (1999 to 2023). They then matched these addresses with food access data from the USDA Food Access Research Atlas, which provides information on household income, vehicle availability, and neighborhood food access.

Data on children's weight and height were collected from birth through adolescence through in-person visits, medical records, and parent or caregiver reports. Researchers analyzed this data alongside the neighborhood information to investigate the relationship between food access and child BMI or obesity.

This collaborative research is published in JAMA Pediatrics.

###

Aris, I.M., “Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity in ECHO.” JAMA Pediatrics. DOI: 10.1001/jamapediatrics.2024.3459.

About ECHO: Launched in 2016, the Environmental influences on Child Health Outcomes (ECHO) Program is a research program in the Office of the Director at the NIH with the mission to enhance the health of children for generations to come. ECHO investigators study the effects of a broad range of early environmental influences on child health and development. For more information, visit echochildren.org.

About the NIH: NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information, visit www.nih.gov.

Media Contacts

For information or to request an interview, contact Rebekah Yeager,  rebekah.yeager@nih.gov.

If you are not a member of the media, but have a general inquiry, please contact  NIHKidsandEnvironment@od.nih.gov.

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ECHO Study Investigates Pollution Exposure and Birth Outcomes in Pregnant Women Living in Historically Redlined Neighborhoods

ECHO Study Investigates Pollution Exposure and Birth Outcomes in Pregnant Women Living in Historically Redlined Neighborhoods

Authors: Teresa Herrera, Akhgar Ghassabian, et al.

 

Who sponsored this study?

The Environmental influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health supported this research.

 

Why was this study needed?

Exposure to tiny air pollutants known as PM2.5 during pregnancy can lead to outcomes like low birth weight and preterm birth. Factors such as weather, government policies, and social conditions can affect how much exposure pregnant women have to these pollutants. One factor that may have affected exposure is redlining, the historical practice of designating certain neighborhoods, often where minority groups lived, as risky investments for lenders. This grading system ranked neighborhoods on an A through D scale—A being the most desirable—which often led to disinvestment and lack of resources in lower-rated areas. While redlining was made illegal following the 1968 Fair Housing Act, it continues to affect the health outcomes of people living in historically redlined areas.

ECHO researchers wanted to learn whether living in historically redlined areas during pregnancy affects air pollution exposure and birth outcomes in New York City (NYC). Understanding what influences PM2.5 levels and their impact on birth outcomes can help improve the health of mothers and their children.

 

What were the study results?

The study found that living in lower-graded or ungraded census tracts during pregnancy was associated with higher exposure to PM2.5. These women also tended to have babies with lower birth weights. This association was strong even when considering factors such as race, ethnicity, and income at individual and community levels.

 

What was this study's impact?

The study supports the literature linking redlining to contemporary outcomes. This study highlights the multifaceted nature of structural racism. Findings from non-graded areas indicate that there are likely additional factors, along with redlining, that play a role in perpetuating modern-day inequality.

 

Who was involved?

The participants were 3,160 pregnant mothers and their babies in the NYC metropolitan area who were enrolled in six ECHO Cohort research sites. The study included pregnant mothers from 2005 to 2022 who had air pollution estimates available for their residential address. Most participants who identified as Black or White lived in neighborhoods that had been given a D grade, the lowest rating. Most participants who identified as Hispanic lived in neighborhoods with B or C grades.

 

What happened during the study?

Researchers used statistical methods to explore whether living in neighborhoods that were historically redlined was associated with higher exposure to air pollution (PM2.5) during pregnancy. They also examined if living in these neighborhoods was associated with the baby's birth weight, the likelihood of being born early, and the chances of having a low birth weight.

Note: Results reported here are for a single study. Other or future studies may provide new information or different results. You should not make changes to your health without first consulting your healthcare professional.

 

What happens next?

The authors note that future research could look at other practices like racial exclusionary zoning to fully understand the ongoing systemic effects of redlining.

 

Where can I learn more?

Access the full journal article, titled “Redlining in New York City: Impacts on Particulate Matter Exposure During Pregnancy and Birth Outcomes,” in Journal of Epidemiology and Community Health.

The content is the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 

Published September 5, 2024

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ECHO Study Investigates Pollution Exposure and Birth Outcomes in Pregnant Women Living in Historically Redlined Neighborhoods

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ECHO Study Evaluates Influence of Neighborhood-Level Poverty and Food Insecurity During Pregnancy on Birthweight

Authors: Izzuddin Aris, Emily Oken, et al.

Weight Gain During Infancy in Children Born Preterm Associated with Higher Risk of Obesity, According to New ECHO Research

Authors: Michael O’Shea, et al.

ECHO Study Suggests No Association Between Maternal Stress in the First Year After Birth and Childhood BMI

Authors: Callie Brown, Charles Wood, et al.

ECHO Cohort Study Finds No Significant Evidence that Prenatal Cannabis Exposure Increases Likelihood of Child Autism Spectrum Disorder

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ECHO Cohort Study Finds No Significant Evidence that Prenatal Cannabis Exposure Increases Likelihood of Child Autism Spectrum Disorder

Authors: Chaela Nutor, Patricia A. Brennan, et al.

 

Who sponsored this study?

This research was supported by the Environmental influences on Child Health Outcomes (ECHO) Program, Office of The Director, National Institutes of Health.

 

Why was this study needed?

With the legalization of cannabis in some areas of the U.S., there has been a decrease in the perception of risk and an increase in cannabis use among pregnant women. While fetal exposure to cannabis has been linked to poorer neonatal and cognitive outcomes, relatively few studies have examined the association between prenatal cannabis exposure and neurodevelopmental outcomes, including autism spectrum disorder (ASD).

 

What were the study results?

The investigators found no evidence that prenatal cannabis exposure increased the likelihood for ASD in the group of children included in the study. There was also no evidence that child sex or gestational age at birth affected how prenatal cannabis exposure related to likelihood of ASD. No other aspects of brain or child development were evaluated in the study.

Note: Results reported here are for a single study. Other or future studies may provide new information or different results. You should not make changes to your health without first consulting your healthcare professional.

 

What was this study's impact?

Although no significant associations were found with ASD outcomes in this study, other studies have found that prenatal cannabis exposure may still be associated with ASD traits or other facets of child development and behavior that were outside of the scope of this study.

 

Who was involved?

This study included 11,570 school-age children from 34 ECHO Cohort research sites across the U.S., including three sites that enrolled children with a higher likelihood of ASD and three sites that enrolled children from neonatal intensive care units (NICU).

 

What happened during the study?

ECHO Cohort researchers gathered data on cannabis use during pregnancy directly from mothers and indirectly from their medical records. They also collected information on ASD diagnosis, as well as caregiver-reported data on the children’s autism-related traits from the ages of 1 to 18 years. The researchers used this information to test whether prenatal cannabis use might be associated with ASD.

 

What happens next?

The researchers are planning another large national study to further examine the relationship between prenatal cannabis exposure and autism traits. Other work could examine whether exposure to cannabis in utero alters brain functioning.

 

Where can I learn more?

Access the full journal article, titled “Examining the Association Between Prenatal Cannabis Exposure and Child Autism Behaviors: A Multi-cohort Investigation in the Environmental influences on Child Health Outcomes (ECHO) Program," in Autism Research.

 

The content is the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Published August 2024

Read the associated article.

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ECHO Cohort Study Finds No Significant Evidence that Prenatal Cannabis Exposure Increases Likelihood of Child Autism Spectrum Disorder

New ECHO Cohort Research Suggests No Significant Association Between Prenatal Cannabis Exposure and Child Autism-Related Outcomes

Posted on by Jodi Snare

Collaborative ECHO research led by Chaela Nutor, MA and Patricia A. Brennan, PhD of Emory University investigates the association between prenatal cannabis exposure and autism spectrum disorder (ASD). The study looked at data from 11,570 school-aged children from across the United States and found no evidence that prenatal cannabis exposure increases the likelihood of ASD, regardless of the child’s sex or gestational age at birth. This research, titled “Examining the Association Between Prenatal Cannabis Exposure and Child Autism Traits: A Multi-cohort Investigation in the Environmental influences on Child Health Outcomes (ECHO) Program,” is published in Autism Research.

This study included children and their mothers from 34 ECHO cohorts across the United States. ECHO researchers gathered data on cannabis use during pregnancy directly from mothers and from their medical records. They also collected information on ASD diagnosis, as well as caregiver-reported data on the children’s autism traits when the children were 1 to 18 years. The researchers used these data and reports to test whether prenatal cannabis use might be associated with ASD.

“With the legalization of cannabis in some areas of the United States, there has been a decrease in the perception of risk and an increase in cannabis use among pregnant women,” said Chaela Nutor. “While fetal exposure to cannabis has been linked to poorer neonatal and cognitive outcomes, relatively few studies have tested the association between prenatal cannabis exposure and autism spectrum disorder.”

The results of this study supported the findings from previous studies showing that initial unadjusted associations between prenatal cannabis exposure and ASD behaviors in school-aged children are no longer significant when controlling for other factors, such as maternal use of other substances during pregnancy.

The researchers are planning another large national study to further investigate the relationship between prenatal cannabis exposure and autism-related behaviors. Future work could examine the role of continued exposure to cannabis after mothers are aware of pregnancy, and other studies could investigate combined exposure to tobacco and cannabis and associated risk for ASD.

Read the research summary.

ECHO Researchers Investigate Link Between Pregnancy Complications and Infant Development

Posted on by Jodi Snare

Collaborative ECHO research led by Carrie Breton, ScD, MPH of the University of Southern California and Christine Ladd-Acosta, PhD of Johns Hopkins University found that preeclampsia and gestational diabetes may be linked to slower biological development in infants. The researchers found that newborns who were exposed to these pregnancy complications were biologically younger than those without exposure—an effect that was most noticeable in female infants. The results of this study provide an important clue about how biological mechanisms in offspring might be affected by common pregnancy complications and how these conditions could be linked to child health outcomes. This research, titled “Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns,” is published in JAMA Network Open.

The study included 1,801 children born between 1998 and 2008 from 12 ECHO cohorts across the United States. ECHO researchers calculated each infant’s epigenetic age—a measurement of their “biological age” based on molecular markers in their cells—using DNA samples collected at birth and compared their biological age to their actual age at birth (measured in pregnancy weeks). Then, the researchers compared the biological ages of newborn babies exposed to pregnancy complications to the biological ages of babies who were not exposed.

“In the future, we plan to continue our research with a larger sample of participants and investigate whether these biological changes detected at birth are linked to health outcomes later in childhood,” said Dr. Breton. “If so, doctors and researchers could use that knowledge to develop targeted interventions that can reduce the adverse effects of preeclampsia and gestational diabetes on children’s health.”

Read the research summary.