Toddler Emotional and Behavioral Problems Decreased Slightly During Pandemic, ECHO Study Finds

<< Back to Research Summaries

Toddler Emotional and Behavioral Problems Decreased Slightly During Pandemic, ECHO Study Finds

Authors: Lauren Shuffrey, Anahid Akbaryan, et al.

 

Who sponsored this study?

The Environmental influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health supported this research.

 

Why was this study needed?

The COVID-19 pandemic disrupted family patterns and children’s environments, both of which play a role in early brain development. Early childhood is a period of rapid brain growth and increased sensitivity to environmental influences, making the early social environment important for children's health and well-being. Previous research raised concerns about the development of infants born during the pandemic, but there is limited evidence on how the pandemic affected the behavioral and emotional well-being of toddlers. In this study, researchers wanted to look at the association between growing up during the pandemic and behavioral outcomes in toddler-aged children.

 

What were the study results?

The study found that children who experienced the pandemic had fewer emotional and behavioral problems compared to children born and assessed before the onset of the pandemic, based on results from the Preschool Child Behavior Checklist (CBCL). Specifically, their scores for internalizing problems, such as anxiety or sadness, were about 1.5 to 2 points lower, and their scores for externalizing problems, such as aggression or hyperactivity, were about 1.7 to 3.2 points lower than those born and assessed before the pandemic.

Although these differences were small, researchers report that they were consistent. The study also found that these links between growing up during the pandemic and lower emotional and behavioral problems were significantly stronger for children whose mothers did not have a bachelor’s degree.

 

What was the study's impact?

The study suggests that toddler-age children may have shown resilience despite the disruptions of the pandemic. These findings could help identify potential protective factors that could have buffered the impact of the pandemic on child behavior and inform future interventions to support children's well-being during and after global crises.

 

Who was involved?

The study included 3,438 toddlers (average age of 2 years) across the U.S. and Puerto Rico. Researchers grouped children based on when they were born and when they were assessed: before the pandemic, born before but assessed after March 2020, or both born and assessed during the pandemic.

 

What happened during the study?

During the study, researchers compared young children’s behavior and emotions before and during the pandemic using data from the ECHO Cohort collected between September 2009 and July 2023. Parents filled out the Preschool CBCL, a commonly used tool to assess the child’s emotions and behaviors, like anxiety, sadness, or hyperactivity. Researchers then analyzed these results to see how the pandemic may have affected children’s emotional and behavioral well-being.

Footnote: Results reported here are for a single study. Other or future studies may provide new information or different results. You should not make changes to your health without first consulting your healthcare professional.

What happens next?

Further research could help researchers identify potential protective factors that may have promoted resilience among children whose daily life was disrupted by the COVID-19 pandemic.

 

Where can I learn more?

Access the full journal article, titled “COVID-19 pandemic exposure and toddler behavioral health in the ECHO Program,” in JAMA Network Open.

 

The content is the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Published September 3, 2025

Access the associated press release.

Toddlers Showed Slightly Fewer Behavioral Problems During COVID-19 Pandemic, NIH Study Finds

Toddlers assessed during the COVID-19 pandemic had slightly fewer emotional and behavioral problems compared to children assessed before the pandemic, suggesting some toddlers may have shown resilience during this time. This finding comes from a study of over 3,000 children across the United States using data from the Environmental influences on Child Health Outcomes (ECHO) Cohort Consortium collected between September 2009 and July 2023.

The COVID-19 pandemic disrupted family patterns and children’s environments, both critical for early brain development and well-being. While earlier research raised concerns about infants born during the pandemic, there is limited information about how toddlers’ emotional and behavioral health might have been affected.

To explore this, the study examined data from 3,438 toddlers (average age of 2 years) across the U.S. and Puerto Rico. Researchers used the Preschool Child Behavior Checklist (CBCL), a parent-reported measure of child behavior and emotions, to compare children assessed before and during the pandemic.

Children were grouped based on when they were born and when their behavior was assessed: before the pandemic, born before but assessed after March 2020, or both born and assessed during the pandemic. Parents completed the CBCL, which asks about behaviors such as anxiety, sadness, and aggression. These reports helped researchers understand how growing up during the pandemic might have influenced toddler emotional and behavioral health.

Key findings include:

  • Children who experienced the pandemic had significantly lower scores for internalizing problems (such as anxiety and sadness) and externalizing problems (such as aggression or hyperactivity) compared to children assessed before the pandemic.
  • Internalizing problem scores were about 1.5 to 2 points lower, and externalizing problem scores were about 1.7 to 3.2 points lower than those born and assessed before the onset of the pandemic.
  • Although the differences were small, they were consistent. The associations were stronger among children whose mothers did not have a bachelor’s degree.

“Our findings suggest that even during periods of widespread pandemic-related disruption, toddler-aged children may have experienced opportunities for resilience,” said study author Anahid Akbaryan, a Research Associate at NYU Grossman School of Medicine. “Future research should explore within-home factors that may have supported child mental health outcomes during this time, such as consistent caregiving routines, household stability, and positive parental coping strategies to identify potential protective influences during times of instability.”

Study author Lauren Shuffrey, PhD, of NYU Grossman School of Medicine, added, “These findings suggest that some families may have adapted in ways that buffered young children from behavioral challenges during the pandemic, highlighting the importance of identifying and strengthening those protective supports.”

The researchers emphasized that further studies are needed to identify these protective factors and develop strategies to help families support child well-being during and after times of global disruptions.

This collaborative research is published in JAMA Network Open.

About ECHO
The ECHO Cohort Consortium is a research program supported by the National Institutes of Health (NIH) with the mission to enhance the health of children for generations to come. ECHO Cohort investigators study the effects of a broad range of early environmental influences on child health and development. For more information, visit echochildren.org.

Media Contacts

For information or to request an interview, contact Rebekah Yeager,  rebekah.yeager@nih.gov.

If you are not a member of the media, but have a general inquiry, please contact  NIHKidsandEnvironment@od.nih.gov.

Connect With Us

echo connectorCheck out the recent issues of our bi-monthly newsletter, the ECHO Connector, for program news and the latest research findings.

To receive the ECHO Connector through email, subscribe here.

Follow the ECHO Program on LinkedIn and X for the latest updates.

Exposure to Certain Flame-retardant Chemicals During Pregnancy May Be Associated with Behavioral Issues in Young Children

Exposure to certain organophosphate esters (OPEs)—chemicals commonly used as flame retardants and plastic softeners in a variety of household and industrial products—during pregnancy was associated with more behavioral issues in young children, according to a new ECHO Cohort study led by Jiwon Oh, PhD and Deborah Bennett, PhD of the University of California, Davis.

Previous research has linked exposure to OPEs during pregnancy with potential adverse effects on child brain development, but more evidence is needed. In this study, researchers investigated the association between prenatal exposure to OPEs and child behaviors. The study included 2,948 mother-child pairs from 12 ECHO Cohort study sites across the U.S., and the investigators used the Child Behavior Checklist for ages 1½–5 to assess each child’s behavior during early childhood.

Among the nine OPEs measured, diphenyl phosphate (DPHP) was detected in almost all pregnant women (99.5%) and had the highest median concentration.  Other frequently detected OPEs included dibutyl phosphate/di-isobutyl phosphate (DBUP/DIBP), bis (1,3-dichloro-2-propyl) phosphate (BDCPP), bis(2-chloroethyl) phosphate (BCETP), bis(2-butoxyethyl) phosphate (BBOEP), and bis(1-chloro-2-propyl) phosphate (BCPP).

“This research builds on a growing body of evidence of potential harm caused by exposures to OPEs,” said Dr. Bennett.

Key Takeaways include:

  • Prenatal exposure to BBOEP (at moderate concentrations rather than high concentrations) was associated with more internalizing behaviors (e.g., anxiety, depression), externalizing behaviors (e.g., aggression, hyperactivity), and total behavior issues in young children.
  • Exposure to BCPP was associated with more externalizing behaviors and total behavior issues.
  • Detectable dipropyl phosphate (DPRP) was associated with fewer externalizing behaviors.
  • Boys showed more behavior issues associated with prenatal BDCPP and BCPP exposure.
  • Children from highly vulnerable neighborhoods—defined by community-level demographics, socioeconomic status, housing, access to transportation, and other factors—exhibited more behavior issues associated with prenatal BCPP exposure.

“While further research is needed, our findings suggest that reducing exposure to this chemical class during pregnancy may help mitigate emotional and behavioral problems in young children,” said Dr. Oh.

This collaborative research, titled “Prenatal Exposure to Organophosphate Ester Flame Retardants and Behavioral Outcomes in Early Childhood in the Environmental influences on Child Health Outcomes (ECHO) Cohort,” is published in Environment International.

Read the research summary.

Exposure to Common Flame-retardant Chemicals During Pregnancy May Be Associated with Behavioral Issues in Young Children, ECHO Study Finds

<< Back to Research Summaries

Exposure to Common Flame-retardant Chemicals During Pregnancy May Be Associated with Behavioral Issues in Young Children, ECHO Study Finds

Author(s): Jiwon Oh, et al.

 

Who sponsored this study?

The Environmental influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health supported this research.

 

Why was this study needed?

Organophosphate esters (OPEs) are chemicals commonly used as flame retardants and plastic softeners in a variety of household and industrial products, including furniture, electronics, infant products, and fabrics. Previous research has linked exposure to OPEs during pregnancy with potential adverse effects on child brain development, but more evidence is needed. In this study, researchers investigated the association between prenatal exposure to OPEs and child behaviors.

 

What were the study results?

Among the nine OPEs measured, diphenyl phosphate (DPHP) was detected in almost all pregnant women (99.5%) and had the highest median concentration. Other frequently detected OPEs included dibutyl phosphate/di-isobutyl phosphate (DBUP/DIBP), bis (1,3-dichloro-2-propyl) phosphate (BDCPP), bis(2-chloroethyl) phosphate (BCETP), bis(2-butoxyethyl) phosphate (BBOEP), and bis(1-chloro-2-propyl) phosphate (BCPP).

Prenatal exposure to BBOEP (at moderate concentrations rather than high concentrations) was associated with more internalizing behaviors (e.g., anxiety, depression, emotional reactivity), externalizing behaviors (e.g., aggression, inattention), and total behavior issues in young children. Exposure to BCPP was associated with more externalizing behaviors and total behavior issues. In contrast, detectable dipropyl phosphate (DPRP) was associated with slightly  fewer externalizing behaviors. Boys showed more behavior issues associated with prenatal BDCPP and BCPP exposure. Children from highly vulnerable neighborhoods—defined by community-level demographics, socioeconomic status, housing, access to transportation, and other factors—exhibited more behavior issues associated with prenatal BCPP exposure.

 

What was the study's impact?

Use of OPEs is increasing, with widespread exposure observed in pregnant women. While further research is needed, this study suggests that reducing exposure to certain chemicals during pregnancy may help mitigate emotional and behavioral problems in young children.

 

Who was involved?

The study included 2,948 mother–child pairs from 12 ECHO Cohort study sites across the United States. Non-Hispanic White (40.2%), non-Hispanic Black (28.6%), and Hispanic (21.3%) mothers were included in the study. Most participating mothers (85.2%) did not experience major pregnancy complications and most of their children (93.2%) were born after at least 37 weeks of pregnancy.

 

What happened during the study?

During the study, researchers collected urine samples from pregnant participants and analyzed them for nine chemical markers of OPE exposure. Later, researchers assessed the child’s behaviors using the Child Behavior Checklist for Ages 1½–5. The researchers then used statistical methods to examine associations between each OPE exposure during pregnancy and behavioral issues in children. The study also evaluated how other factors, like the child’s sex and their social vulnerability, may have influenced the effect of prenatal OPE exposure on their behavior.

Footnote: Results reported here are for a single study. Other or future studies may provide new information or different results. You should not make changes to your health without first consulting your healthcare professional.

What happens next?

Future studies could help researchers better understand the effects of prenatal OPE exposure on child brain development and determine whether reducing these exposures could be beneficial to children’s health and development.

 

Where can I learn more?

Access the full journal article, titled “Prenatal Exposure to Organophosphate Ester Flame Retardants and Behavioral Outcomes in Early Childhood in the Environmental influences on Child Health Outcomes (ECHO) Cohort,” in Environment International.

 

The content is the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Published August, 2025

Read the related research alert.