ECHO Study Investigates Pollution Exposure and Birth Outcomes in Pregnant Women Living in Historically Redlined Neighborhoods

ECHO Study Investigates Pollution Exposure and Birth Outcomes in Pregnant Women Living in Historically Redlined Neighborhoods

Authors: Teresa Herrera, Akhgar Ghassabian, et al.

 

Who sponsored this study?

The Environmental influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health supported this research.

 

Why was this study needed?

Exposure to tiny air pollutants known as PM2.5 during pregnancy can lead to outcomes like low birth weight and preterm birth. Factors such as weather, government policies, and social conditions can affect how much exposure pregnant women have to these pollutants. One factor that may have affected exposure is redlining, the historical practice of designating certain neighborhoods, often where minority groups lived, as risky investments for lenders. This grading system ranked neighborhoods on an A through D scale—A being the most desirable—which often led to disinvestment and lack of resources in lower-rated areas. While redlining was made illegal following the 1968 Fair Housing Act, it continues to affect the health outcomes of people living in historically redlined areas.

ECHO researchers wanted to learn whether living in historically redlined areas during pregnancy affects air pollution exposure and birth outcomes in New York City (NYC). Understanding what influences PM2.5 levels and their impact on birth outcomes can help improve the health of mothers and their children.

 

What were the study results?

The study found that living in lower-graded or ungraded census tracts during pregnancy was associated with higher exposure to PM2.5. These women also tended to have babies with lower birth weights. This association was strong even when considering factors such as race, ethnicity, and income at individual and community levels.

 

What was this study's impact?

The study supports the literature linking redlining to contemporary outcomes. This study highlights the multifaceted nature of structural racism. Findings from non-graded areas indicate that there are likely additional factors, along with redlining, that play a role in perpetuating modern-day inequality.

 

Who was involved?

The participants were 3,160 pregnant mothers and their babies in the NYC metropolitan area who were enrolled in six ECHO Cohort research sites. The study included pregnant mothers from 2005 to 2022 who had air pollution estimates available for their residential address. Most participants who identified as Black or White lived in neighborhoods that had been given a D grade, the lowest rating. Most participants who identified as Hispanic lived in neighborhoods with B or C grades.

 

What happened during the study?

Researchers used statistical methods to explore whether living in neighborhoods that were historically redlined was associated with higher exposure to air pollution (PM2.5) during pregnancy. They also examined if living in these neighborhoods was associated with the baby's birth weight, the likelihood of being born early, and the chances of having a low birth weight.

Note: Results reported here are for a single study. Other or future studies may provide new information or different results. You should not make changes to your health without first consulting your healthcare professional.

 

What happens next?

The authors note that future research could look at other practices like racial exclusionary zoning to fully understand the ongoing systemic effects of redlining.

 

Where can I learn more?

Access the full journal article, titled “Redlining in New York City: Impacts on Particulate Matter Exposure During Pregnancy and Birth Outcomes,” in Journal of Epidemiology and Community Health.

The content is the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 

Published September 5, 2024

ECHO Researchers Identify Effects of Mixed Metal Exposures on Fetal Growth

In a collaborative research effort led by Caitlin Howe, PhD and Margaret Karagas, PhD of Dartmouth College, researchers observed an inverse association between the metalloid antimony and birth weight for gestational age, suggesting that this understudied metalloid may harm fetal growth. Their study, titled “Prenatal metal(loid) mixtures and birth weight for gestational age: a pooled analysis of three cohorts participating in the ECHO Program” is published in Environment International.

The study included approximately 1,000 mother-newborn pairs in three geographically and demographically diverse ECHO cohorts:

  • The Maternal And Developmental Risks from Environmental and Social Stressors (MADRES) study, a predominantly lower-income Hispanic cohort in Los Angeles, California
  • The New Hampshire Birth Cohort Study (NHBCS), a primarily non-Hispanic white cohort in northern New England
  • The Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) study, a Hispanic cohort in northern Puerto Rico.

The team pooled data from these three cohorts, measured multiple metals in the mothers’ urine samples collected during pregnancy and evaluated the associations with birth weight for gestational age using a multipollutant analysis approach. In addition to the findings for antimony, the team reported that the effects of other metals (cobalt, mercury, nickel, tin) on birth weight for gestational age differed by cohort and/or infant sex. The mixture of metals together did not impact birth weight for gestational age. Cadmium and molybdenum individually were not associated with differences in birth weight for gestational age.

“Previous research on this topic has mainly focused on one metal at a time, but individuals are often exposed to multiple metals simultaneously, which may interact in complex ways to impact health,” said Howe.

This research highlights the need to identify major sources of antimony, which may differ depending on the population, such that interventions can be developed to reduce exposure to this toxic metalloid. In the future, the research team would also like to expand their analysis to additional ECHO cohorts and participants, investigate other biomarkers of metal and metalloid exposures, and identify windows in pregnancy when the developing fetus may be most susceptible to these exposures.

Read the research summary.

ECHO Study Finds Pregnant Women Exposed to Variety of Chemicals—Some May Affect Birth Weights

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ECHO Study Finds Pregnant Women Exposed to Variety of Chemicals—Some May Affect Birth Weights

Author(s): John L. Pearce, Brian Neelon, Michael S. Bloom, Jessie P. Buckley, Cande V. Ananth, Frederica Perera, John Vena, and Kelly Hunt

 

Who sponsored this study?

The Environmental influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health.

 

What were the study results?

Findings from the study revealed that moms experienced a broad range of chemical exposure profiles with marked variability in exposure magnitudes across chemical classes and exposure frequencies. Evaluation of health effects found that maternal exposure profiles dominated by higher levels of flame-retardants (i.e., polybrominated diphenyl ethers, PBDEs) were associated to lower birth weights. Exposure profiles with higher levels of polychlorinated biphenyls (PCBs) and perfluoroakyl (PFAS) substances were associated with increased birth weights. PCBs are man-made chemicals that are often found in industrial and commercial products, such as electrical and hydraulic equipment and plasticizers in paints, plastics, and rubber products. PFAS substances can often be found in food packaging, commercial household products, drinking water, and living organisms.

 

What was the study's impact?

ECM provides a promising framework for supporting studies of other exposure mixtures as the resulting mapping benefits visualization and assessment of relationships in complex data.

 

Why was this study needed?

Pregnant women often encounter numerous chemicals that may pose a risk to them and their baby.  Studies seeking to identify health effects in populations that experience such complex exposure scenarios remains difficult. With this study, the researchers tried to improve research of multiple exposures by presenting a mixtures methodology, defined as exposure continuum mapping (ECM), that allows investigators to identify complex exposure patterns (i.e., mixtures) within their study population and evaluate complex health effects.

 

Who was involved?

The team involved a diverse mother-child cohort over 600 women participating in ECHO that also enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development's (NICHD) Fetal Growth Studies from 2009-2012.

 

What happened during the study?

To begin, the team obtained data previously collected from the study population during their participation in the Eunice Kennedy Shriver National Institute of Child Health and Human Development's (NICHD) Fetal Growth Studies. These data included concentrations of endocrine disrupting chemicals (EDCs) measured in blood samples collected from mothers 8-12 weeks into their pregnancy and their infant’s weight at birth. Then, the team analyzed these data with ECM in order to identify the range of EDC exposure profiles experienced by moms during their pregnancy and to examine the relationship to the birth weight of their children.

 

What happens next?

The team will apply ECM to assist investigations of exposure mixtures and other child health outcomes, with particular interest on obesity.

 

Where can I learn more?

For access to software tools see: https://github.com/johnlpearce/

Access the full journal article, titled “Exploring associations between prenatal exposure to multiple endocrine disruptors and birth weight with exposure continuum mapping.”

 

The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 

Published June 2, 2021

 

Access the associated article.

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A review of studies that look at whether exposure to common non-persistent chemicals in consumer products delays the time it takes to become pregnant

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