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DTSTART;TZID=America/New_York:20250514T130000
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SUMMARY:Dr. Christine Ladd-Acosta\, PhD: What is DNA methylation and how can it help us address ECHO scientific priorities and improve child health?
DESCRIPTION:What is DNA methylation and how can it help us address ECHO scientific priorities and improve child health?  \nKey Takeaways:  DNA methylation is a molecular modification of DNA that is instrumental in regulating several essential cellular functions. For example\, it provides a mechanism for cellular differentiation during fetal development\, it controls gene expression\, and it silences one X-chromosome in females\, among other functions. Alterations in DNA methylation have been associated with a wide range of health outcomes in adults and children and have also been associated with environmental exposures. Thus\, it may provide a biologic mechanism for some environmental effects on child health. In addition to providing potential biologic/mechanistic insights\, there is evidence that it could serve as a useful biomarker of exposures and/or health outcomes. This presentation will provide a brief introduction to DNA methylation\, a framework for how it can be examined in ECHO to address scientific priorities\, highlight a few exemplar findings in ECHO to date\, and summarize opportunities and challenges for future studies.  \n  \n  \n  \n  \n  \n  \n  \n  \n  \nDr. Christine Ladd-Acosta\, PhD  \nAssociate Professor\, Department of Epidemiology\nJohns Hopkins Bloomberg School of Public Health \nSpeaker Biography: \nDr. Ladd-Acosta is an Associate Professor in the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health\, with a joint appointment in mental health. Her research focuses on developing and applying epigenomic and genomic epidemiology approaches to improve health\, with a particular concentration on child and neurodevelopmental health outcomes. Her findings have been recognized with a “best original article” award by Environmental Research and results reported in multiple publications have been declared as top 20 advances in autism research by the Interagency Autism Coordinating Committee (IACC). \nDownload the slides
URL:https://echochildren.org/event/dr-christine-ladd-acosta-phd-what-is-dna-methylation-and-how-can-it-help-us-address-echo-scientific-priorities-and-improve-child-health/
CATEGORIES:genetics
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