About ECHO

About ECHO


Leveraging the data from existing, longitudinal cohorts helps to support approaches that can evolve with the science. ECHO capitalizes on the growing number of clinical research networks and technological breakthroughs in pediatric research to investigate the effects of a broad range of early environmental exposures — including physical, chemical, biological, social, behavioral, natural and built environments — on child health and development.
ECHO cohorts will look at existing data to test and analyze their project's hypotheses.  These hypotheses prioritize the five key pediatric outcomes that have a high public health impact:

  • Pre-, Peri-, and Postnatal
  • Child Obesity
  • Airways
  • Neurodevelopment
  • Positive Health

Other areas of focus include policies and practices—for data sharing, harmonization, and analysis; use of biospecimens; publications; and engagement—that will drive best practices for conducting Team Science in the 21st century.

Program Components

NIH has established the essential components of the ECHO program to support multiple, synergistic longitudinal studies of mothers and children. ECHO extends and expands upon existing cohort studies to determine the factors that influence health outcomes in children, from conception to early childhood.

image of children on bikesPediatric Cohorts

ECHO taps existing pediatric cohorts with a goal of enrolling more than 50,000 children from diverse racial, geographic and socioeconomic backgrounds to become part of the ECHO consortium.

image of people in officeCoordinating Center

The ECHO Coordinating Center is the central site responsible for organizing and managing activities and logistics for all collaborative components of the initiative, including oversight and coordination of the multi-cohort study design, evaluation of the process, and tissue sample storage.

image of hands on keyboardData Analysis Center

The ECHO Data Analysis Center is responsible for managing all existing and new data from ECHO pediatric cohorts.

image of children playingChildren's Health and Exposure Analysis Resource Core

The ECHO Children's Health and Exposure Analysis Resource (CHEAR) Core serves as a consortium resource for laboratory and statistical analyses of personal environmental exposures in existing and future collections of biological samples.

counselor and childPatient Reported Outcomes Core

Researchers in the ECHO Patient Reported Outcomes (PRO) Core capture the voices and experiences of children and their families who are participating in the pediatric cohort consortium.

kids talking imageIDeA States Pediatric Clinical Trials Network

ECHO leverages NIH-funded institutions that are part of the IDeA Program to build an IDeA States Pediatric Clinical Trials Network.